Transib: Difference between revisions
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Transib is a superfamily of interspersed repeats DNA transposons. It was named after the Trans-Siberian Express.Cite error: The <ref> tag name cannot be a simple integer (see the help page).
Transib was first described in 2003, discovered in the Drosophila melanogaster genome. They encode a DDE transcriptase.Cite error: The <ref> tag name cannot be a simple integer (see the help page). Divergent clades of this superfamily has since been discovered and dubbed Transib, TransibSU, Chapaev and Chapaev3. The differences lie in the domain organization of the code transcriptase.[1]: fig. 2
Transib is also notable as the source of the two Recombination-activating genes. An active transposon with RAG1/2-like genes has been discovered in B. belcheri (Chinese lancelet).[2]
References
- ^ Kapitonov VV, Koonin EV (2015-04-28). "Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon". Biology Direct. 10 (1): 20. doi:10.1186/s13062-015-0055-8. PMC 4411706. PMID 25928409.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Huang, S; Tao, X; Yuan, S; Zhang, Y; Li, P; Beilinson, HA; Zhang, Y; Yu, W; Pontarotti, P; Escriva, H; Le Petillon, Y; Liu, X; Chen, S; Schatz, DG; Xu, A (30 June 2016). "Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination" (PDF). Cell. 166 (1): 102–14. doi:10.1016/j.cell.2016.05.032. PMC 5017859. PMID 27293192.