(+)-cis-2-Aminomethylcyclopropane carboxylic acid

From Wikipedia, the free encyclopedia
Jump to: navigation, search
(+)-cis-2-Aminomethylcyclopropane carboxylic acid
Stereo, skeletal formula of (+)-cis-2-aminomethylcyclopropane carboxylic acid
(+)-CAMP molecule
Identifiers
CAS number 36489-13-1 N
PubChem 1502041
ChemSpider 1236854 YesY
ChEMBL CHEMBL230115 YesY
Jmol-3D images Image 1
Properties
Molecular formula C5H9NO2
Molar mass 115.13 g mol−1
Density 1.275 g/mL
Boiling point 256.9 °C (494.4 °F; 530.0 K)
log P −0.721
Acidity (pKa) 4.157
Basicity (pKb) 9.840
Isoelectric point 7.01
Related compounds
Related cycloalkanes ACPD
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references
Not to be confused with Cyclic adenosine monophosphate.

(+)-cis-2-Aminomethylcyclopropane carboxylic acid ((+)-CAMP) is a GABA agonist selective for the GABAA (previously known as GABAC) subtype.[2][3]

References[edit]

  1. ^ "AC1LT400 - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 11 July 2005. Identification and Related Records. Retrieved 7 October 2011. 
  2. ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry 75 (6): 2602–10. PMID 11080214. 
  3. ^ Carland, JE; Moorhouse, AJ; Barry, PH; Johnston, GA; Chebib, M (2004). "Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability". The Journal of Biological Chemistry 279 (52): 54153–60. doi:10.1074/jbc.M410625200. PMID 15485818.