(+)-cis-2-Aminomethylcyclopropane carboxylic acid
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| (+)-cis-2-Aminomethylcyclopropane carboxylic acid | |
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-CAMP.svg) |
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(1S,2R)-2-(Aminomethyl)cyclopropane-1-carboxylic acid[1] |
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| Identifiers | |
| CAS number | 36489-13-1  |
| PubChem | 1502041 |
| ChemSpider | 1236854  |
| ChEMBL | CHEMBL230115 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C5H9NO2 |
| Molar mass | 115.13 g mol−1 |
| Density | 1.275 g/mL |
| Boiling point |
256.9 °C, 530 K, 494 °F |
| log P | −0.721 |
| Acidity (pKa) | 4.157 |
| Basicity (pKb) | 9.840 |
| Isoelectric point | 7.01 |
| Related compounds | |
| Related cycloalkanes | ACPD |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
(+)-cis-2-Aminomethylcyclopropane carboxylic acid ((+)-CAMP) is a GABA agonist selective for the GABAA-ρ (previously known as GABAC) subtype.[2][3]
References [edit]
- ^ "AC1LT400 - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 11 July 2005. Identification and Related Records. Retrieved 7 October 2011.
- ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry 75 (6): 2602–10. PMID 11080214.
- ^ Carland, JE; Moorhouse, AJ; Barry, PH; Johnston, GA; Chebib, M (2004). "Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability". The Journal of Biological Chemistry 279 (52): 54153–60. doi:10.1074/jbc.M410625200. PMID 15485818.
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