(R)-3-hydroxyacid-ester dehydrogenase

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(R)-3-hydroxyacid-ester dehydrogenase
Identifiers
EC number 1.1.1.279
CAS number 114705-02-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (R)-3-hydroxyacid-ester dehydrogenase (EC 1.1.1.279) is an enzyme that catalyzes the chemical reaction

ethyl (R)-3-hydroxyhexanoate + NADP+ \rightleftharpoons ethyl 3-oxohexanoate + NADPH + H+

Thus, the two substrates of this enzyme are ethyl (R)-3-hydroxyhexanoate and NADP+, whereas its 3 products are ethyl 3-oxohexanoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase. This enzyme is also called 3-oxo ester (R)-reductase.

References[edit]

  • Heidlas J, Engel KH, Tressl R (1988). "Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast". Eur. J. Biochem. 172 (3): 633–9. doi:10.1111/j.1432-1033.1988.tb13936.x. PMID 3280313.