(R)-4-hydroxyphenyllactate dehydrogenase

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(R)-4-hydroxyphenyllactate dehydrogenase
Identifiers
EC number 1.1.1.222
CAS number 101754-02-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) is an enzyme that catalyzes the chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ \rightleftharpoons 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD+, and NADP+, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.

References[edit]

  • Bode R, Lippoldt A and Birnbaum D (1986). "Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa". Biochem. Physiol. Pflanzen 181: 189–198. 
  • Leelayoova S, Marbury D, Rainey PM, Mackenzie NE, Hall JE (1992). "In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes". J. Protozool. 39 (2): 350–8. doi:10.1111/j.1550-7408.1992.tb01329.x. PMID 1578411.