(S)-2-hydroxy-acid oxidase

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(S)-2-hydroxy-acid oxidase
Identifiers
EC number 1.1.3.15
CAS number 9037-63-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxy acid + O2 \rightleftharpoons 2-oxo acid + H2O2

Thus, the two substrates of this enzyme are (S)-2-hydroxy acid and O2, whereas its two products are 2-oxo acid and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-2-hydroxy-acid:oxygen 2-oxidoreductase. Other names in common use include glycolate oxidase, hydroxy-acid oxidase A, hydroxy-acid oxidase B, glycolate oxidase, oxidase, L-2-hydroxy acid, hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, and L-2-hydroxy acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, FMN.

Structural studies[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1AL7, 1AL8, 1GYL, 1TB3, and 2NZL.

References[edit]

  • Blanchard M, Green DE, Nocito-Carroll V and Ratner S (1946). "l-Hydroxy acid oxidase" (PDF). J. Biol. Chem. 163 (1): 137–144. 
  • FRIGERIO NA, HARBURY HA (1958). "Preparation and some properties of crystalline glycolic acid oxidase of spinach". J. Biol. Chem. 231 (1): 135–57. PMID 13538955. 
  • KUN E, DECHARY JM, PITOT HC (1954). "The oxidation of glycolic acid by a liver enzyme". J. Biol. Chem. 210 (1): 269–80. PMID 13201588. 
  • Nakano M, Danowski TS (1966). "Crystalline mammalian L-amino acid oxidase from rat kidney mitochondria". J. Biol. Chem. 241 (9): 2075–83. PMID 5946631. 
  • Nakano M, Ushijima Y, Saga M, Tsutsumi Y, Asami H (1968). "Aliphatic L-alpha-hydroxyacid oxidase from rat livers: purification and properties". Biochim. Biophys. Acta. 167 (1): 9–22. doi:10.1016/0005-2744(68)90273-8. PMID 5686300. 
  • Phillips DR, Duley JA, Fennell DJ, Holmes RS (1976). "The self-association of L-alpha hydroxyacid oxidase". Biochim. Biophys. Acta. 427 (2): 679–87. PMID 1268224. 
  • Schuman M, Massey V (1971). "Purification and characterization of glycolic acid oxidase from pig liver". Biochim. Biophys. Acta. 227 (3): 500–20. doi:10.1016/0005-2744(71)90003-9. PMID 5569122.