(S)-2-hydroxy-fatty-acid dehydrogenase

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(S)-2-hydroxy-fatty-acid dehydrogenase
Identifiers
EC number 1.1.1.99
CAS number 37250-33-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (S)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.99) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxystearate + NAD+ \rightleftharpoons 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (S)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

References[edit]

  • Huang WY, Tang J (1970). "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245 (9): 2189–93. PMID 4909888.