(S)-scoulerine 9-O-methyltransferase

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(S)-scoulerine 9-O-methyltransferase
Identifiers
EC number 2.1.1.117
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (S)-scoulerine 9-O-methyltransferase (EC 2.1.1.117) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (S)-scoulerine \rightleftharpoons S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and (S)-scoulerine, whereas its two products are S-adenosylhomocysteine and (S)-tetrahydrocolumbamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References[edit]

  • Muemmler S, Rueffer M, Nagakura N, Zenk MH (1985). "S-Adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase, a highly stereo- and regiospecific enzyme in tetrahydroberberine biosynthesis". Plant Cell Reports 4: 36–39. doi:10.1007/BF00285501.