(Z)-4-Amino-2-butenoic acid

From Wikipedia, the free encyclopedia
Jump to: navigation, search
(Z)-4-Amino-2-butenoic acid[1]
(Z)-4-Amino-2-butenoic acid.png
CACA molecule
Abbreviations CACA
CAS number 55199-25-2 N
PubChem 6603697
ChemSpider 5036011 YesY
Jmol-3D images Image 1
Image 2
Molecular formula C4H7NO2
Molar mass 101.10 g mol−1
Solubility in water 124 mg/mL
S-phrases S22 S24/25
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA (previously known as GABAC) subtype.[2][3][4]


  1. ^ cis-4-Aminocrotonic acid at Sigma-Aldrich
  2. ^ Qian, H; Dowling, JE (1996). "Selective agonists for GABAC receptors". Trends in neurosciences 19 (5): 190. doi:10.1016/0166-2236(96)85451-8. PMID 8723205. 
  3. ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry 75 (6): 2602–10. PMID 11080214. 
  4. ^ Reis, GM; Duarte, ID (2007). "Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid". Life Sciences 80 (14): 1268–73. doi:10.1016/j.lfs.2006.12.015. PMID 17316706.