(deoxy)nucleoside-phosphate kinase

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(deoxy)nucleoside-phosphate kinase
Identifiers
EC number 2.7.4.13
CAS number 37278-20-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (deoxy)nucleoside-phosphate kinase (EC 2.7.4.13) is an enzyme that catalyzes the chemical reaction

ATP + deoxynucleoside phosphate \rightleftharpoons ADP + deoxynucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1DEK and 1DEL.

References[edit]

  • BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5". J. Biol. Chem. 240: 439–45. PMID 14253449.