(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
[pyruvate dehydrogenase (lipoamide)] phosphatase
Identifiers
EC number 3.1.3.43
CAS number 9073-70-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) is an enzyme that catalyzes the chemical reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O \rightleftharpoons [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

Thus, the two substrates of this enzyme are pyruvate dehydrogenase (acetyl-transferring) phosphate and H2O, whereas its two products are pyruvate dehydrogenase (acetyl-transferring) and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.

References[edit]

  • Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148 (2): 327–42. doi:10.1016/0003-9861(72)90151-8. PMID 4401694. 
  • Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. 27: 41–9. PMID 3004826.