1,2-Dichloropropane

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1,2-Dichloropropane[1]
1,2-dichloropropane skeletal.png
Identifiers
CAS number 78-87-5 YesY
PubChem 6564
ChemSpider 6316 YesY
UNII RRZ023OFWL YesY
KEGG C19034 N
ChEMBL CHEMBL44641 YesY
Jmol-3D images Image 1
Properties
Molecular formula C3H6Cl2
Molar mass 112.99 g mol−1
Appearance Colorless liquid
Odor like chloroform
Density 1.156 g/cm3
Melting point −100 °C (−148 °F; 173 K)
Boiling point 95 to 96 °C (203 to 205 °F; 368 to 369 K)
Solubility in water 0.26 g/100 mL (at 20 °C)
Hazards
R-phrases R11 R20/22
S-phrases S16 S24
Flash point 16 °C (61 °F; 289 K)
Autoignition temperature 557 °C (1,035 °F; 830 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.[2]

Uses[edit]

1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals.[2] It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.[3]

Carcinogenity[edit]

Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.[4][5]

Data from animal studies show tumor growth in the liver and mammary glands.[6] Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.[7]

References[edit]

  1. ^ 1,2-Dichloropropane at Sigma-Aldrich
  2. ^ a b Manfred Rossberg, Wilhelm Lendle, Gerhard Pfleiderer, Adolf Tögel, Eberhard-Ludwig Dreher, Ernst Langer, Heinz Rassaerts, Peter Kleinschmidt, Heinz Strack, Richard Cook, Uwe Beck, Karl-August Lipper, Theodore R. Torkelson, Eckhard Löser, Klaus K. Beutel, Trevor Mann “Chlorinated Hydrocarbons” in Ullmann's Encyclopedia of Industrial Chemistry 2006, Wiley-VCH, Weinheim. doi:10.1002/14356007.a06_233.pub2.
  3. ^ ToxFAQs for 1,2-Dichloropropane
  4. ^ Report by the Japanese Ministry of Health, Labour and Welfare
  5. ^ Article in the Yomiuri Shinbun
  6. ^ CDC - NIOSH Pocket Guide to Chemical Hazards
  7. ^ Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)