1,2-dehydroreticulinium reductase (NADPH)

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1,2-dehydroreticulinium reductase (NADPH)
Identifiers
EC number 1.5.1.27
CAS number 130590-58-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1,2-dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) is an enzyme that catalyzes the chemical reaction

(R)-reticuline + NADP+ \rightleftharpoons 1,2-dehydroreticulinium + NADPH + H+

Thus, the two substrates of this enzyme are (R)-reticuline and NADP+, whereas its 3 products are 1,2-dehydroreticulinium, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-reticuline:NADP+ oxidoreductase. This enzyme is also called 1,2-dehydroreticulinium ion reductase. This enzyme participates in alkaloid biosynthesis i.

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