1,4-lactonase

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1,4-lactonase
Identifiers
EC number 3.1.1.25
CAS number 37278-38-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1,4-lactonase (EC 3.1.1.25) is an enzyme that catalyzes the generic chemical reaction:

a 1,4-lactone + H2O \rightleftharpoons a 4-hydroxyacid

Thus, the two substrates of this enzyme are 1,4-lactone and H2O, whereas its product is 4-hydroxyacid.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1,4-lactone hydroxyacylhydrolase. This enzyme is also called gamma-lactonase. This enzyme participates in galactose metabolism and ascorbate and aldarate metabolism. It employs one cofactor, calcium.

Structural studies[edit]

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DG0, 2DG1, and 2DSO.

References[edit]

  • Fishbein WN, Bessman SP (1966). "Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase". J. Biol. Chem. 241 (21): 4835–41. PMID 4958984. 
  • Fishbein WN, Bessman SP (1966). "Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra". J. Biol. Chem. 241 (21): 4842–7. PMID 4958985.