1,5-anhydro-D-fructose dehydratase
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| 1,5-anhydro-D-fructose dehydratase | |||||||
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| Identifiers | |||||||
| EC number | 4.2.1.111 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
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In enzymology, a 1,5-anhydro-D-fructose dehydratase (EC 4.2.1.111) is an enzyme that catalyzes the chemical reaction
- 1,5-anhydro-D-fructose
1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2OHence, this enzyme has one substrate, 1,5-anhydro-D-fructose, and two products, 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose and H2O.
It catalyzes two steps in the anhydrofructose pathway process.[1]
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming). Other names in common use include 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydrolyase, 1,5-anhydro-D-arabino-hex-2-ulose dehydratase, AFDH, AF dehydratase, and 1,5-anhydro-D-fructose hydro-lyase.
[edit] References
- ^ IUBMB - Anhydrofructose Pathway
- Yu S, Refdahl C, Lundt I (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.
- Yu S, Fiskesund R (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
- Yu S (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
[edit] See also
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