1,5-anhydro-D-fructose dehydratase

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1,5-anhydro-D-fructose dehydratase
Identifiers
EC number 4.2.1.111
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a 1,5-anhydro-D-fructose dehydratase (EC 4.2.1.111) is an enzyme that catalyzes the chemical reaction

1,5-anhydro-D-fructose \rightleftharpoons 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O

Hence, this enzyme has one substrate, 1,5-anhydro-D-fructose, and two products, 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose and H2O.

It catalyzes two steps in the anhydrofructose pathway process.[1]

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming). Other names in common use include 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydrolyase, 1,5-anhydro-D-arabino-hex-2-ulose dehydratase, AFDH, AF dehydratase, and 1,5-anhydro-D-fructose hydro-lyase.

References[edit]

  • Yu S, Refdahl C, Lundt I (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094. 
  • Yu S, Fiskesund R (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618. 
  • Yu S (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041. 

See also[edit]