1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide

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1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide
CAS 93101-02-1.svg
Systematic (IUPAC) name
(E)-4-chloro-N-(1-(4-nitrophenethyl)piperidin-2-ylidene)benzenesulfonamide
Clinical data
Legal status
  • Legal
Identifiers
CAS number 93101-02-1 N
ATC code ?
PubChem CID 13373555
ChemSpider 10544260 YesY
Synonyms W-18
Chemical data
Formula C19H20ClN3O4S 
Mol. mass 421.91 g/mol
Physical data
Melt. point 157–158 °C (315–316 °F)
 N (what is this?)  (verify)

1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18) is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. It was invented by the chemists Edward Knaus, Brent Warran and Theodore Ondrus in 1981.[1]

This compound was found to be around 10,000x more potent than morphine in animal studies.[citation needed]

It has never been studied in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.[original research?] Tolerance and dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to carfentanil and so would most likely cause pronounced tachyphylaxis following repeated dosing, as is seen with the potent fentanyl analogues.[original research?]

It was recently found to be in several drugs seized by police in Canada. The seized drugs were believed to be a fentanyl analog but after analysis were identified as 1-(4-nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide. This is of great concern to health officials and police due to the extreme potency of this substance.[citation needed] It was being sold as oxycontin 80 tablets. The counterfeit oxycodone pills were white with OC 80 markings on them. They were sold in Montreal, Toronto and Vancouver in late 2013. No seizures have been made in 2014. There were several non-fatal overdoses.[2]

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