|Systematic (IUPAC) name|
|Mol. mass||421.91 g/mol|
|Melt. point||157–158 °C (315–316 °F)|
|(what is this?)|
1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18) is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. It was invented by the chemists Edward Knaus, Brent Warran and Theodore Ondrus in 1981.
This compound was found to be around 10,000x more potent than morphine in animal studies, however due to its structural differences from other opioid drugs it would be difficult to represent as being "substantially similar in chemical structure" to any controlled drugs. This makes it likely that it would not be illegalized under drug analog laws.
It has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal. Tolerance and dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to carfentanil and so would most likely cause pronounced tachyphylaxis following repeated dosing, as is seen with the potent fentanyl analogues.
It was recently found to be in several drugs seized by police in Canada. The seized drugs were believed to be a fentanyl analogue but after analysis were identified as 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide. This is of great concern to health officials and police due to the extreme potency of this substance. It was being sold as oxycontin 80 tablets. The counterfeit oxycodone pills were white with OC 80 markings on them. They were sold in Montreal , Toronto and Vancouver in late 2013. No seizures have been made in 2014. There were several non-fatal overdoses.
- Edward E. Knaus, Brent K. Warren, Theodore A. Ondrus. Analgesic substituted piperidylidene-2-sulfon(cyan)amide derivatives. US Patent 4468403