1-Amino-2-propanol

From Wikipedia, the free encyclopedia
Jump to: navigation, search
1-Amino-2-propanol
Aminopropanol.png
Identifiers
CAS number 78-96-6 YesY
PubChem 4
ChemSpider 3 YesY
UNII UE40BY1BZW YesY
EC number 220-532-9
KEGG C05771 YesY
ChEMBL CHEMBL326602 YesY
Jmol-3D images Image 1
Properties
Molecular formula C3H9NO
Molar mass 75.11 g mol−1
Appearance liquid
Odor ammonia-like
Density 0.973 g/mL (18 °C) [1]
Melting point 1.74 °C (35.13 °F; 274.89 K)
Boiling point 159.46 °C (319.03 °F; 432.61 K)
Solubility in water soluble
Solubility soluble in alcohol, ether, acetone, benzene, CCl4
Refractive index (nD) 1.4479
Hazards
NFPA 704
Flammability code 2: Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur. Flash point between 38 and 93 °C (100 and 200 °F). E.g., diesel fuel Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Flash point 77 °C (171 °F; 350 K)
LD50 4.26 g/kg (rat, oral)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

1-Amino-2-propanol (isopropanolamine) is a chemical compound with the formula C3H9NO. It is an amino alcohol. The term "isopropanolamine" may also refer more generally to the additional homologs diisopropanolamine (DIPA) and triisopropanolamine (TIPA).

It can be prepared by the addition of aqueous ammonia to propylene oxide.

Applications[edit]

The isopropanolamines are basic chemicals that can be used in many applications to achieve basicity, buffering and alkalinity objectives. They are good solubilizers of oil and fat, so they are used to neutralize fatty acids and sulfonic acid-based surfactants.

1-Amino-2-propanol is typically used in metal working fluid, waterborne coating, personal care products, and in the production of titanium dioxide and polyurethanes.[2]

1-Amino-2-propanol is an intermediate in the synthesis of a variety of pharmaceutical drugs and is the very basic building block of the opioid methadone.

The chemical derivative 1-dimethylamino-2-propanol can be synthesized via Eschweiler-Clarke methylation of 1-amino-2-propanol using formic acid and formaldehyde.[citation needed]

See also[edit]

References[edit]

  1. ^ Amino-2-propanol at Sigma-Aldrich
  2. ^ "Monoisopropanolamine". Nanjing HBL International. Retrieved October 24, 2012.