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CAS number 174643-75-5 N
PubChem 9952105
ChemSpider 8127716 YesY
Jmol-3D images Image 1
Molecular formula C27H31NO
Molar mass 385.54 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine is a stimulant of the piperidine class which acts as a potent and selective dopamine reuptake inhibitor.[1][2] It is closely related to vanoxerine and GBR-12,935, which in contrast are piperazines.

See also[edit]


  1. ^ Dutta AK, Coffey LL, Reith ME (January 1997). "Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity". Journal of Medicinal Chemistry 40 (1): 35–43. doi:10.1021/jm960638e. PMID 9016326. 
  2. ^ Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME (January 2002). "Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules". Journal of Medicinal Chemistry 45 (3): 654–62. doi:10.1021/jm010316x. PMID 11806716.