1-alkyl-2-acetylglycerol O-acyltransferase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
1-alkyl-2-acetylglycerol O-acyltransferase
Identifiers
EC number 2.3.1.125
CAS number 114704-90-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase (EC 2.3.1.125) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol \rightleftharpoons CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol

Thus, the two substrates of this enzyme are acyl-CoA and 1-O-alkyl-2-acetyl-sn-glycerol, whereas its two products are CoA and 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase. This enzyme is also called 1-hexadecyl-2-acetylglycerol acyltransferase. This enzyme participates in ether lipid metabolism.

References[edit]

  • Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells". J. Biol. Chem. 263 (6): 2593–6. PMID 3422635.