1-alkylglycerophosphocholine O-acyltransferase

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1-alkylglycerophosphocholine O-acyltransferase
Identifiers
EC number 2.3.1.63
CAS number 58693-63-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1-alkylglycerophosphocholine O-acyltransferase (EC 2.3.1.63) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine \rightleftharpoons CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acyl-1-alkyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase. This enzyme participates in ether lipid metabolism.

References[edit]

  • Waku K, Nakazawa Y. "Acyltransferase activity to 1-O-alkyl-glycero-3-phosphorylcholine in sarcoplasmic reticulum". J. (Tokyo). Biochem. (4): 459–66. PMID 5488773. 
  • Waku K, Nakazawa Y. "Acyltransferae activity to 1-acyl-, 1-O-alkenyl-, and 1-O-alkyl-glycero-3-phosphorylcholine in Ehrlich ascites tumor cells". J. (Tokyo). Biochem. (2): 495–7. PMID 4644313.