1-deoxy-D-xylulose-5-phosphate synthase

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1-deoxy-D-xylulose-5-phosphate synthase
Identifiers
EC number 2.2.1.7
CAS number 202218-79-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) is an enzyme that catalyzes the chemical reaction

pyruvate + D-glyceraldehyde 3-phosphate \rightleftharpoons 1-deoxy-D-xylulose 5-phosphate + CO2

Thus, the two substrates of this enzyme are pyruvate and D-glyceraldehyde 3-phosphate, whereas its two products are 1-deoxy-D-xylulose 5-phosphate and CO2.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating). Other names in common use include 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating), and DXP-synthase. This enzyme participates in biosynthesis of steroids.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2O1S and 2O1X.

References[edit]