1-phosphatidylinositol 4-kinase

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1-phosphatidylinositol 4-kinase
Identifiers
EC number 2.7.1.67
CAS number 37205-54-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol \rightleftharpoons ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies[edit]

As of late 2007, the structure has only been solved for this enzyme. Part of the enyzme was crystallized with its activating partner frequenin.[1]

References[edit]

  1. ^ Strahl T, Huttner IG, Lusin JD et al. (October 2007). "Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)". J. Biol. Chem. 282 (42): 30949–59. doi:10.1074/jbc.M705499200. PMID 17720810. 
  • Colodzin M, Kennedy EP (1965). "Biosynthesis of diphosphoinositide in brain". J. Biol. Chem. 240 (10): 3771–80. PMID 4284712. 
  • Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328–37. PMC 1270113. PMID 4290722. 
  • Walker DH, Dougherty N, Pike LJ (1988). "Purification and characterization of a phosphatidylinositol kinase from A431 cells". Biochemistry. 27 (17): 6504–11. doi:10.1021/bi00417a046. PMID 2851325. 
  • Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644–6. doi:10.1038/332644a0. PMID 2833705. 
  • Barylko B; Gerber, SH; Binns, DD; Grichine, N; Khvotchev, M; Südhof, TC; Albanesi, JP (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087.