10-Deacetylbaccatin

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10-Deacetylbaccatin III
Deacetylbaccatin.png
10-Deacetylbaccatin III molecule
Names
IUPAC name
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)- 12b-(Acetyloxy)-12-(benzoyloxy)- 1,2a,3,4,4a,6,9,10,11,12,12a,12b- dodecahydro-4,6,9,11-tetrahydroxy- 4a,8,13,13-tetramethyl-7,11-methano- 5H-cyclodeca(3,4)benz(1,2-b) oxet-5-one
Other names
10-Deacetylbaccatin III
10-Deacetylbaccatine III
Identifiers
32981-86-5 N
ChEBI CHEBI:18193 YesY
ChEMBL ChEMBL393912 YesY
ChemSpider 135935 YesY
Jmol-3D images Image
PubChem 154272
Properties
C29H36O10
Molar mass 544.59 g/mol
Appearance colorless solid
Melting point 234 °C (453 °F; 507 K)
insoluble
Solubility soluble in methanol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

10-Deacetylbaccatins are a series of closely related natural organic compounds isolated from the Pacific yew tree (Taxus brevifolia) and related species. 10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere).

10-deacetylbaccatin III 10-O-acetyltransferase converts 10-Deacetylbaccatin to baccatin III. (acetyl-CoA + 10-deacetylbaccatin III \rightleftharpoons CoA + baccatin III)

External links[edit]