10-hydroxydihydrosanguinarine 10-O-methyltransferase

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10-hydroxydihydrosanguinarine 10-O-methyltransferase
Identifiers
EC number 2.1.1.119
CAS number 144388-39-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 10-hydroxydihydrosanguinarine 10-O-methyltransferase (EC 2.1.1.119) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine \rightleftharpoons S-adenosyl-L-homocysteine + dihydrochelirubine

Thus, the two substrates of this enzyme are S-adenosyl methionine and 10-hydroxydihydrosanguinarine, whereas its two products are S-adenosylhomocysteine and dihydrochelirubine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References[edit]

  • De-Eknamkul W, Tanahashi T and Zenk MH (1992). "Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia". Phytochemistry 31 (8): 2713–2717. doi:10.1016/0031-9422(92)83617-8.