11β-hydroxysteroid dehydrogenase type 1

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Hydroxysteroid (11-beta) dehydrogenase 1
Protein HSD11B1 PDB 1xu7.png
PDB rendering based on 1xu7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HSD11B1 ; 11-DH; 11-beta-HSD1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1
External IDs OMIM600713 MGI103562 HomoloGene68471 ChEMBL: 4235 GeneCards: HSD11B1 Gene
EC number 1.1.1.146
RNA expression pattern
PBB GE HSD11B1 205404 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3290 15483
Ensembl ENSG00000117594 ENSMUSG00000016194
UniProt P28845 P50172
RefSeq (mRNA) NM_001206741 NM_001044751
RefSeq (protein) NP_001193670 NP_001038216
Location (UCSC) Chr 1:
209.86 – 209.91 Mb
Chr 1:
193.22 – 193.26 Mb
PubMed search [1] [2]

11β-hydroxysteroid dehydrogenase type 1, or 'cortisone reductase' is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.

In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.

It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Moreover, 18alpha-glycyrrhizic acid from the root of Glycyrrhiza glabra was discovered as an inhibitor [1] A study from 2014 found that Epigallocatechin gallate from Green tea can also potently inhibit this reaction,[2] which might partly explain the anti-stress properties of Green tea consumption.

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.[3]

Cortisol-cortisone equilibrium

See also[edit]

References[edit]

  1. ^ Classen-Houben, D; Schuster, D; Da Cunha, T; Odermatt, A; Wolber, G; Jordis, U; Kueenburg, B (Feb 2009). "Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid.". The Journal of steroid biochemistry and molecular biology 113 (3-5): 248–52. doi:10.1016/j.jsbmb.2009.01.009. PMID 19429429. Retrieved 26 July 2014. 
  2. ^ Hintzpeter, Jan; Stapelfeld, Claudia; Loerz, Christine; Martin, Hans-Joerg; Maser, Edmund; Sun, Kang (3 January 2014). "Green Tea and One of Its Constituents, Epigallocatechine-3-gallate, Are Potent Inhibitors of Human 11β-hydroxysteroid Dehydrogenase Type 1". PLoS ONE 9 (1): e84468. doi:10.1371/journal.pone.0084468. PMID 24404164. 
  3. ^ "Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1". 

Further reading[edit]