On 15 April 1777 Captain George Price's company (organized on 18 January 1777 in the Virginia State Troops with volunteers from Frederick and Augusta Counties) was transferred to the regiment. On 11 May 1777 the regiment was assigned to the 3rd Virginia Brigade of the Main Army and was reorganized to eight companies on 1 November 1777. The regiment saw action at the Battle of Brandywine, Battle of Germantown, and the Battle of Monmouth. The unit was reassigned to the 2nd Virginia Brigade on 22 July 1778, and it was reorganized to nine companies and redesignated as the 7th Virginia Regiment on 12 May 1779. It was relieved from the 2nd Virginia Brigade on 4 December 1779 and assigned to the Southern Department.
The unit was captured on 12 May 1780 at the Siege of Charleston and subsequently disbanded on 1 January 1781.