|Systematic (IUPAC) name|
|Mol. mass||443.490 g/mol|
|(what is this?)|
14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs discovered in the 1960s, with > ×100 times the potency of morphine. It is a derivative of hydroxycodeinone, being the 14-cinnamate ester. In another paper, Buckett assigns the potency as 177 with a range (depending on animal and test) of ×101 - ×310. It may be of interest to researchers that the allyl group in this compound and in allylprodine overlay very closely.
- Lien, E. J.; Tong, G. L.; Srulevitch, D. B.; Dias, C. (1978). "QSAR of Narcotic Analgetic Agents" (pdf). NIDA Research Monograph 1978 (22): 186–196. PMID 30907.
- Buckett, W. R. (1965). "Some Pharmacological Studies With 14-Cinnamoyloxycodeinone". The Journal of Pharmacy and Pharmacology 17 (11): 759–760. PMID 4379812.
- 'The relationship between analgesic activity, acute toxicity and chemical structure in esters of 14-hydroxycodeinone' W.R.Buckett J. Pharm. Pharmacol., 1964, 16, Suppl., 68T-71T
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