|Centuries:||14th century – 15th century – 16th century|
|Decades:||1470s 1480s 1490s – 1500s – 1510s 1520s 1530s|
|Years:||1497 1498 1499 – 1500 – 1501 1502 1503|
|1500 by topic|
|Arts and science|
|Architecture - Art|
|State leaders - Sovereign states|
|Birth and death categories|
|Births - Deaths|
|Establishments and disestablishments categories|
|Establishments - Disestablishments|
|Art and literature|
|1500 in poetry|
|Ab urbe condita||2253|
|Bahá'í calendar||−344 – −343|
|English Regnal year||15 Hen. 7 – 16 Hen. 7|
|Chinese calendar||己未年 (Earth Goat)
4196 or 4136
— to —
庚申年 (Metal Monkey)
4197 or 4137
|- Vikram Samvat||1556–1557|
|- Shaka Samvat||1422–1423|
|- Kali Yuga||4601–4602|
|Japanese calendar||Meiō 9
|Minguo calendar||412 before ROC
|Thai solar calendar||2043|
|Wikimedia Commons has media related to 1500.|
The year was seen as being especially important by many Christians in Europe, who thought it would bring the beginning of the end of the world. Their belief was based on the phrase "half-time after the time", when the apocalypse was due to occur, which appears in the Book of Revelation and was seen as referring to 1500.
- January 5 – Duke Ludovico Sforza recaptures Milan, but is soon driven out again by the French.
- January 26 – Spanish navigator Vicente Yáñez Pinzón reaches the northern coast of Brazil.
- February 17 – Battle of Hemmingstedt: The Danish army fails to conquer the peasants' republic of Dithmarschen.
- April 22 – Portuguese navigator Pedro Álvares Cabral officially discovers Brazil and claims the land for the Kingdom of Portugal. He has 13 vessels with him.
- July 14 – the Muscovites defeat the Lithuanians and the Poles in the Battle of Vedrosha.
- August – Second Battle of Lepanto: The Turkish fleet of Kemal Reis defeats the Venetians. The Turks proceed to capture Modon and Coron, the "two eyes of the Republic".
- August 10 – Diogo Dias discovers an island which he names St Lawrence (after the saint's day on which it was first sighted), later to be known as Madagascar
- November 11 – Treaty of Granada: Louis XII of France and Ferdinand II of Aragon agree to divide the Kingdom of Naples between them.
- November 16 – Emperor Go-Kashiwabara accedes to the throne of Meiō era Japan.
- December 24 – The Siege of the Castle of St. George ends and the island of Cephalonia is captured by a joint Venetian–Spanish fleet.
- December 31 – The last of the incunabula are published.
- Europe's population is estimated at 56.7 million (Spielvogel).
- Heinrich Cornelius Agrippa is admitted to baccalaureate.
- Saxony's mint at Annaberg begins producing guldengroschens.
- Although other reports exist, it is thought that the last wolf in England was killed this year, making the species extinct in that country. The wolf is thought to have been killed in Allithwaite, in Cumbria. However, reports of wolf sightings and laws concerning wolf bounties existed in rural areas of the north until the 18th century.
- January 6 – John of Ávila, Spanish mystic and saint (d. 1569)
- February 22 – Cardinal Rodolfo Pio da Carpi, Italian humanist (d. 1564)
- February 24 – Charles V, Holy Roman Emperor (d. 1558)
- March 12 – Reginald Pole, Cardinal Archbishop of Canterbury (d. 1558)
- April 12 – Joachim Camerarius, German classical scholar (d. 1574)
- April 23
- May 17 – Federico II Gonzaga, Duke of Mantua (d. 1540)
- November 3 – Benvenuto Cellini, Italian goldsmith and sculptor (d. 1571)
- Johannes Aal, Swiss theologian and composer (d. 1553)
- Charles Dumoulin, French jurist (d. 1566)
- Wu Cheng'en, Chinese novelist (d. 1582)
- Heinrich Faber, German music theorist (d. 1552)
- Francisco de Moraes, Portuguese writer (d. 1572)
- Mem de Sá, Governor-General of Brazil (d. 1572)
- April 10 – Michael Tarchaniota Marullus, Greek scholar, poet and soldier (b. c. 1453)
- May 29
- June 26 – Edmund Tudor, Duke of Somerset (b. 1499)
- September 2 – Albert III, Duke of Saxony (b. 1443)
- September 15 – John Morton, Archbishop of Canterbury (b. c. 1420)
- October 6 – John Alcock, English churchman (b. c. 1430)
- October 21 – Emperor Go-Tsuchimikado of Japan (b. 1442)
- Juan Pérez de Gijón, Spanish composer (b. 1460)
- Stefano Infessura, humanist writer (b. c. 1435)
- Fyodor Kuritsyn, Russian statesman