17Beta Hydroxysteroid dehydrogenase
From Wikipedia, the free encyclopedia
| 17β-Hydroxysteroid dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.51 | ||||||||
| CAS number | 9015-81-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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17β-Hydroxysteroid dehydrogenases (17β-HSD), also known as 17-ketosteroid oxidoreductases, HSD17B or simply as 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.[1][2]
Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
Genes [edit]
Genes coding for 17β-HSD include:
- HSD17B1
- HSD17B2
- HSD17B3
- HSD17B4
- HSD17B6
- HSD17B7
- HSD17B8
- HSD17B10
- HSD17B11
- HSD17B12
- HSD17B13
- HSD17B14
Clinical significance [edit]
Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.
References [edit]
- ^ Labrie F, Luu-The V, Lin SX, et al. (January 1997). "The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology". Steroids 62 (1): 148–58. PMID 9029730.
- ^ Charles G. D. Brook; Daniel Truong, M.D; Peter Clayton; William Carroll, Rosalind Brown (22 September 2011). Brook's Clinical Pediatric Endocrinology. John Wiley & Sons. p. 288. ISBN 978-1-4443-1673-5. Retrieved 29 April 2012.
- 17 beta-Hydroxysteroid Dehydrogenases at the US National Library of Medicine Medical Subject Headings (MeSH)
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