Nebraska barely escaped from Kirksville with a win, managing only one touchdown against the medical students from Missouri. The Cornhuskers utilized their larger average size to control Kirksville, twice preventing preventing scores on two significant attempts. This was the only time these teams would meet. 
After a four-year break, Doane arrived in Lincoln to resume the oldest active series between the Cornhuskers and its opponents. It was a one-sided affair with three Nebraska touchdowns before the half and two more after, while the Cornhuskers notched their third straight shutout victory and extended the series lead over Doane to 7-2. 
Nebraska traveled to Minneapolis in an attempt to avenge their sole loss from the previous season, and again riding high on a streak of shutout wins. It was not to be, however, as the dominant Golden Gophers completely shut down the Cornhuskers and sent them home with no points and lagging in the series 0-2. 
Nebraska bounced right back from the thrashing in Minneapolis by completely shutting down Iowa State 17-0. The Cyclones accumulated only 75 yards and three first downs on the day. The success of the Cornhuskers was significant when taking into account that almost half of the Nebraska linemen were sidelined with injuries from the previous game. Nebraska improved to 4-2 over Iowa State. 
Nebraska met the Wisconsin Badgers for the first time, traveling to Milwaukee to face off with another northern squad. It was Nebraska's second painful defeat from a northern team of the year, as Wisconsin had little trouble putting the Cornhuskers away 18-0. Still, coach Booth had praise for his players, stating that Nebraska played "100% better" than in the earlier defeat by Minnesota. 
Nebraska met Missouri on neutral ground in Omaha, on the field where the Bugeaters of old thrice defeated the Omaha YMCA. Once again bouncing back and putting the shutout on the other side of the scoreboard, The Cornhuskers demolished Missouri in convincing fashion with 51 unanswered points to move ahead in the series 7-3.
Kansas managed one touchdown in their annual contest with Nebraska, thanks to a lost Cornhusker fumble, but it was Nebraska's day to put points on the board as the Cornhuskers scored with relative ease all through the game. Nebraska pulled up to match Kansas and even the series at 5-5. 
Having defeated one team from Lawrence, Kansas two weeks prior, Nebraska welcomed a new team to Nebraska also hailing from Lawrence, the squad from the Haskell Institute. At that time, Haskell was an all-grades school but not yet a college, as they did not offer college level classes until many year later. Perhaps Nebraska was overconfident, or the Haskell team performed admirably, as the Cornhuskers found themselves behind 0-10 by halftime. After regrouping for the second half, Nebraska managed to shut Haskell down and score 18 points of their own to come up with the season-closing win.