Coach Stiehm was already established as the winningest football coach in Nebraska history when he returned for his fifth year, having led the Cornhuskers to conference titles in every year of his tenure to date, and riding a record five straight conference titles overall. Nebraska was justifiably feared by every program in the nation, and this year the legendary Notre Dame football program would finally join in the fight with Nebraska on the field. With ten returning starters, the Cornhuskers appeared to be unstoppable.
Fourteen years had passed since Drake last appeared in Lincoln, back when the Cornhuskers hosted their opponents at the old Antelope Field, and the Bulldogs made their first appearance on Nebraska Field apparently without being intimidated, as they rather surprised the Cornhuskers by managing two touchdowns during the course of the game. However, any moral victory Drake obtained by scoring on Nebraska did not affect the final outcome brought by the Cornhuskers posting 48 points of their own. Nebraska improved to 4-1 all time against the Bulldogs 
University records show that Nebraska hosted Kansas State on this date and defeated the Aggies yet again with a shutout victory of 31-0. However, the University's 1916 yearbook, which reviews the football season of 1915, does not mention this game. The yearbook's narrative instead transitions from the Drake game directly into a short sentence regarding the Washburn game, which followed this one. Kansas State's defeat left them still winless against Nebraska, 0-5. 
Written accounts of this game, the first ever meeting between Nebraska and Notre Dame, compare it favorably against the 7-0 Nebraska victory over Minnesota in 1913, and the 6-6 tie against Michigan in 1911. Notre Dame played effectively and created a worthy struggle for the Cornhuskers, who managed to come back from a 13-7 halftime deficit and win by one point. Since Minnesota suspiciously disappeared from Nebraska's annual schedule after their 1913 defeat, it was clear that Notre Dame would be more than worthy as the program's new annual marquee contest. 
Nebraska traveled to Ames for their first appearance on Iowa State's new Clyde Williams Field, and made relatively easy work of the Cyclones on their own turf, recording another shutout victory on the year. To Iowa State's credit, however, the 21 Cornhusker points would be the lowest points scored against any opponent in 1915 except for Notre Dame. Iowa State's chances to catch up to Nebraska in the series were beginning to look bleak, as the Cornhuskers held a dominant lead at 11-3-1. 
As it happened for the Kansas State game, records show the Cornhusker win over Nebraska Wesleyan, while the annual yearbook fails to mention the game. The 30-0 defeat kept NWU winless all time against Nebraska in five tries. 
It was another in what was becoming a string of disappointments for the Jayhawks, as Nebraska scored more touchdowns than Kansas was able to muster in first downs. The Cornhuskers continued pulling away from the Jayhawks in the series, 14-8. 
It was not the Iowa of previous years that came into Lincoln this time, as the Cornhuskers easily dispatched the Hawkeyes 52-7 in front of the homecoming crowd, which was the most points ever scored against Iowa by Nebraska to date. The Cornhuskers pulled farther ahead of Iowa in the series, 10-4-3. 
Coach Stiehm concluded yet another conference championship season, going 5-0 for conference titles, handing the Cornhuskers an amazing streak of six straight Missouri Valley titles, an accomplishment never matched by any other conference foe, nor ever again repeated by Nebraska. Coach Stiehm departed the program during the offseason, but in his time with Nebraska he secured a career record of 35-2-3 (.913), the best career record of all Nebraska head coaches before and since. The program's overall record improved for the sixth straight year, to 153-47-11 (.751), while their conference record also improved again, to 19-2-2 (.870).