After the Sewanee win, Alabama traveled to Nashville where they lost their only game of the season against Vanderbilt 16–12. After the loss, the Crimson Tide rebounded with wins at LSU and Georgia and at Birmingham over Mississippi A&M on Thanksgiving to close the season.
Scott opened his first fall practice on September 1. At that time, ten players from previous Alabama squads returned and included T. L. Brown, Jack Hovater, Walter E. Hovater, Ralph Lee Jones, E. B. Lenoir, Emmet Noland, J. T. O'Connor, Isaac Rogers, Tram Sessions and Riggs Stephenson. After two weeks of practice, Scott divided the players into four teams in order to determine starting line-ups. At his time Scott also did not utilize a quarterback, but instead would simply snap the ball directly to the runner. Before game preparation began for their game against Birmingham–Southern, Issac Rogers was selected as team captain for the season by the returning lettermen on September 25. Rogers was previously elected to serve as team captain for the 1918 season that was cancelled.
Nearly after two years since their previous home game during the 1917 season, Alabama opened the 1919 season against Birmingham–Southern and shutout the Panthers 27–0 in the first all-time game between the schools. The opening kickoff was at 1:30 and was played in a newly expanded University Field with seating for 800 spectators. E. B. Lenoir starred in the game for Alabama as he scored a touchdown in each of the first three quarters that gave the Crimson White a 20–0 lead. Charles Bartlett scored the final points of the game with his fourth quarter touchdown that made the final score 27–0.
In their second game, Alabama shutout their SIAA rival, the Ole MissRebels 49–0 at Tuscaloosa. After being held scoreless for the first ten minutes, Alabama scored their first touchdown on E. B. Lenoir run late in the quarter. A pair of second quarter touchdown runs from first Riggs Stephenson and then by Charles Bartlett that made the halftime score 18–0. In the third quarter, the Crimson Tide scored 25 points and included a pair of long touchdown scores. The long scores came first on a 76-yard Lenoir run and the second on a 65-tard interception return by Stephenson. Lenoir and Stephenson each scored another touchdown as did J. T. O'Connor and make the final score 49–0. The victory improved Alabama's all-time record against Ole Miss to 9–2–1.
Behind a strong passing game, Alabama defeated the Howard (now known as Samford University) Bulldogs 48–0 at Tuscaloosa. Touchdowns in the game were scored twice each by E. B. Lenoir and Riggs Stephenson and one apiece by Isaac M. Boone, Tram Sessions and Joe Sewell. In the game, the Crimson offense was dominant both running and passing the ball in the victory. The victory improved Alabama's all-time record against Howard to 8–0.
As they entered their game against the Marion Military Institute, many of the Alabama supporters viewed the game against the Cadets as just a practice game before their anticipated match-up against Sewanee. On a Friday afternoon, Alabama defeated the Cadets 61–0 at Tuscaloosa for their fourth consecutive shutout to open the season. Touchdowns in the game were scored three times by J. H. Emmett, twice each by Charles Bartlett and E. B. Lenoir, and one apiece by Walter E. Hovater and Morgan. The victory improved Alabama's all-time record against Marion to 6–0.
In what was the most anticipated game of the season, the entire University population and educators traveled to Birmingham for their game against Sewanee. In the game Alabama defeated the Tigers 40–0 at Rickwood Field, in the largest margin of victory ever for Alabama over Sewanee to date. Alabama took an early 7–0 lead in the first quarter on a 15-yard Riggs Stephenson touchdown run and then extended it to 14–0 at halftime on a 45-yard Walter E. Hovater touchdown run in the second. Alabama then closed the game with four E. B. Lenoir touchdown runs, two in the third and two in the fourth quarter. The victory improved Alabama's all-time record against Sewanee to 3–9–2.
A week after their victory over Sewanee, Alabama traveled to Nashville where they were defeated by the VanderbiltCommodores 16–12 on a muddy field for their only loss of the season. On their first drive of the game, Alabama took the ball to the Vanderbilt two-yard line, but then fumbled the ball that was recovered by Josh Cody of the Commodores to end the scoring threat. The second Alabama fumble resulted in the first touchdown of the game. Early in the second quarter, Riggs Stephenson fumbled the ball that was recovered by Tommy Zerfoss and returned 35-yards for a 7–0 Vanderbilt lead. They further extended their lead to 13–0 at halftime on a 20-yard Grailey Berryhill touchdown run.
Alabama rallied in the second half with a pair of two-yards Stephenson touchdown runs in the third and fourth quarter that made the score 13–12. Cody then provided for the final margin in the 16–12 Commodores' victory with his 30-yard field goal in the fourth quarter. The loss brought Alabama's all-time record against Vanderbilt to 0–5.
After they suffered their only loss of the season at Vanderbilt, Alabama traveled to Baton Rouge where they shutout the LSUTigers 23–0. After a scoreless first half that saw two drives end inside the Tigers ten-yard line due to fumbles, Alabama took a 3–0 lead in the third quarter on a 20-yard Joe Sewellfield goal. The Crimson Tide sealed the win with three touchdowns in the fourth quarter scored on short runs by Sewell, E. B. Lenoir and Riggs Stephenson. The victory improved Alabama's all-time record against LSU to 4–3.
After their road win at LSU, Alabama traveled to Atlanta where they shutout the GeorgiaBulldogs 6–0. The only points in the game came on a pair of J. T. O'Connor field goals. The first was from 45-yards in the first and the second from 25-yards in the second quarter. Both teams played strong defense throughout the game, and Georgia nearly pulled out a win when James Cheeves intercepted an Alabama pass in the final seconds of the game and made a sizable return before he was tackled by the Crimson Tide. The victory improved Alabama's all-time record against Georgia to 4–7–3.
In their final game of the season, Alabama defeated the Mississippi A&M (now known as Mississippi State University) Aggies 14–6 on Thanksgiving at Rickwood Field. After a scoreless first half, H. S. Little scored the Aggies' only points of the game with his 80-yard kickoff return that opened the third quarter. Alabama then took the lead later in the third on a short Riggs Stephenson touchdown run. They then made the final score 14–6 in the fourth after T. L. Brown blocked an A&M punt that was recovered by Isaac Rogers in the endzone for a touchdown. The victory improved Alabama's all-time record against Mississippi A&M to 7–4–1.