A category 1 struck Tampico, Mexico in early September after moving northwest from the Gulf of Mexico. After it dissipated on September 8, an extremely heavy rainfall event ensued across central Texas, which continued into September 11. In Williamson County, Texas, a new 18-hour rainfall record was set for the United States as 36.40 inches (925 mm) was recorded at Thrall; the storm total rainfall there was 39.71 inches (1,009 mm). The deluge led to one of the most destructive floods in the history of San Antonio, Texas. Water rose to 7 feet (2.1 m) deep in the city, forcing people to evacuate vertically within taller buildings. The most significant river floods occurred on the Little and San Gabriel rivers, where 159 people perished. Combined with the death toll from elsewhere across the region, 215 people died due to this storm and damages were estimated at $19 million (1921 USD).
A Cape Verde-type hurricane, Three formed about 500 miles east of the island of Trinidad, and organized into a tropical storm soon after forming. It moved westward and struck the Windward Islands as a Category 1 hurricane. It then made an eventual curve in the eastern Caribbean Sea and grazed the Dominican town of Palo Bonito as a Category 3 hurricane, and almost immediately after landfall was downgraded into a Category 2 hurricane. It tracked northward as a Category 2 hurricane and after a short lull was upgraded back to a Category 3 hurricane and kept moving to the north. At approximately the same latitude as the Georgia - Florida border, the system shifted to the west-northwest and struck the island of Bermuda as a Category 2 hurricane before curving toward the northeast. It became an extratropical cyclone well off the coast of Newfoundland and accelerated before dissipating about 100 miles off the southern tip of Greenland .
The most notable storm of the season was the Tampa Bay hurricane of 1921. It developed in the southwestern Caribbean Sea on October 20. It tracked north-northwestward, steadily strengthening into a hurricane on October 22. The storm turned more north-northeastward, and upon reaching the Gulf of Mexico on October 24 it rapidly intensified to a 140 mph Category 4. It weakened as it continued to the northeast, making landfall north of Clearwater on October 25 as a Category 3 hurricane. It crossed Florida, turned eastward across the Atlantic, and became extratropical on October 28 southwest of Bermuda. Its small and quick nature, as well as well-executed warnings, only caused $3 million in damage (1921 USD), with 6 casualties.