Mesmer had played guard on Georgetown's 1927-28, 1928-29, and 1929-30 teams before graduating in 1930. Less than two years after graduation, he was hired at the age of 23 as the Hoyas' head coach. A popular sports figure on campus, he would coach Georgetown for seven seasons, leaving after the end of the 1937-38 season with an overall record of 53-76. Although his teams would go 36-20 (.643) at home, they would manage only a 17-56 (.233) record on the road, and he would have only two winning seasons – 1933-34 and 1936-37 – during his tenure.
It was common practice at this time for colleges and universities to include non-collegiate opponents in their schedules, with the games recognized as part of their official record for the season, and the games played against the Crescent Athletic Club and the Brooklyn Knights of Columbus therefore counted as part of Georgetown's won-loss record for 1931-32. It was not until 1952, after the completion of the 1951-52 season, that the National Collegiate Athletic Association (NCAA) ruled that colleges and universities could no longer count games played against non-collegiate opponents in their annual won-loss records.