The 1941–42 Palestine League was the eighth season of league football in the British Mandate for Palestine. The defending champions were Hapoel Tel Aviv.
The Palestine League was divided into three regional divisions (Haifa, Jerusalem, Southern) with playoffs at the end of the season.
The Haifa League was cancelled on 5 March 1942  and a cup competition was played instead. Homenetmen Jerusalem won the Jerusalem League, and Maccabi Tel Aviv won the Southern League.
The championship was won by Maccabi Tel Aviv.
1. Hapoel Rishon LeZion's matches against Beitar Tel Aviv and Degel Zion Tel Aviv were both given as 0–0 without points due to infringements from both involved clubs (in each match).
Homenetmen Jerusalem won the Jerusalem League. R.A.M.C. Jerusalem and Elitzur Jerusalem withdrew from the league.
1. The match between Degel Zion Jerusalem and Christian Club Jerusalem was given as a 0–0 without points, due to infringements on behalf of both teams.