The 1942–43 Coppa Italia was the ninth edition of the tournament and the last before the suspenction of soccer competitions in Italy dued to World War II related events. The Coppa Italia would have restored only several years later, in the summer of 1958.
All teams from Serie A (16) and Serie B (18) took part to this competition. After a short elimination round, 32 clubs were admitted to the final phase. All the matches were played in a single leg, homefields were decided by drawing except for the final match.