February 12 - Minor league outfielder Gordon Houston becomes the first player in Organized Baseball to die during active duty in World War II. Houston had played with Texarkana in 1940.
March 18 - Jackie Robinson and Nate Moreland request try-outs with the White Sox. Sox manager Jimmie Dykes praises Robinson's baserunning to Pittsburgh Courier sportswriter Herman Hill, saying that "he stole everything but my infielders' gloves." Dykes goes on record to the Courier, saying "Personally, I would welcome Negro players on the White Sox and I believe every one of the other fifteen managers would do so likewise. As for the players, they'd all get along too." Ultimately, Dykes is unable to even consider offering contracts to either, stating that it is a matter for club owners, league officials, and the Commissioner of Baseball to allow it.
May 13 - Jim Tobin of the Boston Braves almost single-handedly beats the Chicago Cubs at Braves Field, 6–5, by pitching a five-hitter and hitting three consecutive home runs. Tobin, who hit a pinch-homer the day before, becomes the only pitcher in modern history to collect three home runs in a Major League game. His fourth at-bat results in a fly ball caught against the fence in left field.
August 23 - Babe Ruth dons a uniform for the first time in 7 years for a hitting exhibition against Walter Johnson at Yankee Stadium. On Johnson's fifth pitch, Ruth hit a drive into the lower right field stands as the crowd thundered its approval. On the final pitch, Ruth hit a towering upper-deck shot that was just foul. He circled the bases doffing his cap and saluting the roaring crowd with every step. Ruth and Johnson then left the field together to a thunderous ovation. $80,000 was raised for the Army-Navy relief fund.
September 11 - Chicago CubscatcherPaul Gillespie homers in his first major league at bat. In 1945 he will homer in his final major league at bat and become the only player in MLB history to do both.
September 27 - The St. Louis Cardinals clinch the National League pennant on the last day of the regular season by defeating the Chicago Cubs, 9-2, in the first game of a double header at Sportsman's Park, St. Louis. The Cardinals also win Game 2 of the double header and finish the season with a record of 106-48, giving them the most victories by any National League team since Pittsburgh's 110 wins in 1909. Meanwhile the Brooklyn Dodgers win their season finale, 4-3, against Philadelphia to end the season in second place at 104-50.
December 1 - At major league meetings in Chicago, World War II travel restrictions are the order of the day. Owners decide to restrict travel to a three-trip schedule rather than the customary four. Spring training in 1943 will be limited to locations north of the Potomac or Ohio rivers and east of the Mississippi.
September 2 - Henry Thielman, pitched from 1902 to 1903 baseball for the New York Giants, Cincinnati Reds and Brooklyn Superbas
September 26 - Joe Giannini, 54, shortstop for the 1911 Boston Red Sox
October 3 - Pinky Hargrave, catcher for the Washington Senators, St. Louis Browns, Detroit Tigers and Boston Braves between 1923 and 1930
November 8 - Birdie Cree, 60, outfielder who spent his entire career with the New York Highlanders/Yankees from 1908–1915, while hitting .292 in 742 games
November 14 - Scrappy Carroll, 82, Outfielder for three teams from 1884-1887.
November 15 - Joe Gunson, 79, catcher/outfielder who played four seasons in the majors from 1884, 1889, 1892-1893.
November 24 - Frank Owen, 62, pitcher for the Detroit Tigers and Chicago White Sox from 1901–1908, who posted an 82-67 with a 2,55 ERA
November 30 - Slim Love, 52, pitcher who posted a 28-21 record with a 3.04 ERA in six seasons with the Senators, Yankees and Tigers
December 5 - Val Picinich, 46, catcher in 1307 games for the Philadelphia Athletics, Washington Senators, Boston Red Sox, Cincinnati Reds, Brooklyn Robins/Dodgers and Pittsburgh Pirates between 1916 and 1933
December 6 - Amos Rusie, 71, pitcher who won 245 games by age 27 in a 10-year career (1889–98), mainly with the New York Giants; led NL in ERA twice and in strikeouts five times, twice topping 300; his powerful delivery was major reason for 1893 change in pitching distance from 50 feet to 60 feet 6 inches