The Rams were the first to score with a 1-yard run by fullback Dick Hoerner in the second quarter. The Browns answered back with an NFL Championship record 52-yard field goal by Lou Groza. They later took the lead with a 17-yard touchdown pass from Otto Graham to Dub Jones. The Browns led at halftime 10–7.
In the third quarter Larry Brink landed a hard tackle on Graham causing him to fumble the ball. Andy Robustelli picked up the ball on the Cleveland 24 and returned it to the Cleveland 2. On the third play of the drive, "Deacon" Dan Towler ran the ball in for a touchdown from the one-yard line giving the Rams a 14–10 lead.
Early in the fourth quarter, the Rams increased their lead with a Bob Waterfield 17-yard field goal. The Browns answered back with an 8-play, 70-yard drive that ended with a 5-yard touchdown run by Ken Carpenter, tying the game at 17–17. Twenty-five seconds later, late in the fourth quarter, Tom Fears beat defenders Cliff Lewis and Tommy James and received a Norm Van Brocklin pass at midfield. Fears raced to the endzone for a 73-yard touchdown, securing a Rams 24–17 win and the 1951 NFL title.