The 49ers would win their first ever road game on October 14 against the Pittsburgh Steelers after losing their first 7 in team history. The Niners would be in playoff contention all year long, finishing 7–4–1, just a half game out of first place in the National Conference. Their biggest win of the season was a 44–17 victory over their Californian rivals, the Los Angeles Rams.
Frankie Albert and Y.A. Tittle would split time at quarterback, with Albert throwing for 1116 yards, while Tittle would lead the club with 8 TD's and completing 55.3% of his passes. Joe Perry would once again lead the team in rushing, with 677 yards, and add 3 TD's, and wide receiver Gordie Soltau would lead the club with 59 completions for 826 yards and 7 TD's.