The West dominated the East, 411 to 187 in total yards. West quarterback Fran Tarkenton of the Minnesota Vikings was named "Back of the Game" after he completed 8 of 13 passes for 172 yards. The "Lineman of the Game" honors went to the West’s Terry Barr of the Detroit Lions; Barr had 106 yards receiving on three receptions.
Frank Ryan, the quarterback of the Cleveland Browns' who had defeated the Baltimore Colts in the 1965 NFL Championship Game, was knocked out of the Pro Bowl when he was sacked in the third quarter by a group of defenders including the Colts' Gino Marchetti. Some thought that Marchetti, who was playing in his tenth Pro Bowl, was trying to teach Ryan a lesson for considering running up the score against the Colts in the championship game. Marchetti denied this, and he and Ryan remained on good terms.