This was the third time that the Tigers had hosted the All-Star Game (at the previous two in 1941 and 1951, Tiger Stadium had been called Briggs Stadium). This would be the last time Tiger Stadium hosted the All-Star Game, as when it returned to Detroit in 2005, the Tigers had moved to their new home at Comerica Park.
This was the first American League win since the second All-Star Game of 1962, and would be their last until the 54th All-Star Game in 1983. Over the twenty game stretch from 1963–1982, the American League would go 1–19; the worst stretch for either league in the history of the exhibition.
Jake O'Donnell would retire from umpiring after the 1971 season, after only three years on the job, but would go on to work as a long time referee in the NBA. His work in this game makes him the only person to officiate in a Major League Baseball All-Star Game, and an NBA All-Star Game.
In the third inning, Hank Aaron launched a two out solo home run (his first career All-Star Game home run) off of Blue to give the NL a 3-0 lead.
The AL responded in the bottom of the third inning. With Dock Ellis still pitching for the NL, Luis Aparicio singled to lead off the inning. Reggie Jackson was sent up to pinch hit for the pitcher, Vida Blue, and hit a two run home run. Rod Carew walked. Three batter later, with two outs, Frank Robinson hit a two run home run to give the AL a 4-3 lead.