Royals Stadium had not even been open for four months when it hosted this, its first All-Star Game. The game had been hosted in Kansas City once before (1960) when the Kansas City Athletics had been the host team at Kansas City's Municipal Stadium. After this game was played, the Royals did not host another All-Star Game until they were awarded the 2012 All-Star Game.
Scoring began in the bottom of the second inning, with Rick Wise in his second and final inning of pitching for the NL. Reggie Jackson led off with a double, and came home when the next batter, Amos Otis, singled. This would be the beginning and end of scoring for the American League.
The National League wasted no time coming back, taking advantage of new pitcher, Bert Blyleven, in the top of the third inning. Darrell Evans, pinch hitting for Rick Wise, walked, and was forced out at second base when Pete Rose hit into a fielder's choice. Joe Morgan walked. César Cedeño's single scored Rose, and sent Morgan to third base. Hank Aaron singled to Murcer who threw out Cedeño at third, but not before Morgan had scored to give the NL a 2-1 lead.
The NL added a single run in the top of the fourth inning, as Johnny Bench, the first hitter AL relief pitcher Bill Singer faced, hit a lead off home run.
In the top of the fifth inning, the NL scoring continued off of Bill Singer. Joe Morgan led off with a double. Three hitters later, with two outs, Bobby Bonds hit a two run home run, bringing the score to 5-1.
In the top of the sixth inning, Nolan Ryan came in to pitch in relief, though the outcome was virtually identical to the previous inning. Ron Santo led off with a walk. Two batters later with one out, Willie Davis, pinch hitting for the pitcher, Don Sutton, hit a two run home run to extend the NL lead to 7-1, and closing out scoring for the game.
Rick Wise was credited with the win. Bert Blyleven was credited with the loss. Jim Brewer was credited with the save.
This was the 25th and final All-Star Game appearance for Willie Mays. Having appeared in every game from 1954 to 1973, no player has played in as many All-Star Games as Mays.
Catfish Hunter was removed from the game in the second inning after Billy Williams hit a line drive that hit Hunter's right hand, breaking his thumb. He missed two weeks of the regular season.
This All-Star Game saw 54 players (28 for the NL and 26 for the AL) enter the game. This became a new All-Star Game record for participating players.
Buddy Bell became the second son of a former All-Star (Gus Bell) to appear in an All-Star Game.
In total, there were 18 future hall of famers involved with the game. The non-players involved in the 1973 All-Star Game that have been inducted into the Baseball Hall of Fame are Sparky Anderson, Dick Williams, Whitey Herzog, and Nestor Chylak.