Buffalo's season was troubled from the start, as the team was in a contract dispute with star running back O.J. Simpson. Simpson had been demanding a trade, before finally agreeing to a three-year, $2.5 million contract.
The Bills started the season 2–2, before losing their final ten games of the season. Quarterback Joe Ferguson only started the first seven games before being sidelined for the season with a back injury. Backup quarterback Gary Marangi started Buffalo's final seven games, all losses.
Note: 1976 was the final year in which the NFL draft was seventeen rounds; it would be reduced to twelve rounds in 1977.
The Bills' 1976 draft produced four long-time starters with their first four picks. First round pick Mario Clark played for seven seasons with the Bills. Offensive guard Ken Jones played for the Bills for eleven years. Offensive tackle Joe Devlin played every game of his 14-year career with the Bills, playing in all 191 regular-season games until his retirement after the 1989 season. Defensive end Ben Williams played for the Bills for 10 years; he was a Pro Bowler and second-team All-Pro for the 1982 season.