The Colts were embarrassed at home in week two by the putrid Patriots, losing 16–14 for New England's lone win of 1990.
On December 22, 1990, Monday Night Football was played 2 days early on Saturday Night. The 5-8 Colts played at home as underdogs against the Washington Redskins. Trailing 14-25 in the 4th quarter, Jeff George would lead an improbable and spectacular comeback which included 2 4th quarter touchdowns to tie the game with little time left. The Colts intercepted Mark Rypien and it was returned for the go ahead touchdownwn. The Colts pulled off the upset in dramatic fashion. This was one of Jeff George's memorable games of his career as it was a thriller. He threw 3 touchdowns and did not throw any interceptions.