2'-O-methylation

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2'-O-methyl-adenosine, a modified adenosine.

2'-O-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl group of the ribose moiety of a nucleoside. 2'-O-methylated nucleosides are found in the functionally essential regions of the ribosome and spliceosome.[1] Also, 2'-O-methylation of adenosine in an RNA prevents adenosine deaminase from editing it to an inosine.[2]

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References[edit]

  1. ^ Kiss T (2001). "Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs". EMBO J. 20 (14): 3617–3622. doi:10.1093/emboj/20.14.3617. PMC 125535. PMID 11447102. 
  2. ^ Beal PA, Maydanovych O, Pokharel S (2007). "The chemistry and biology of RNA editing by adenosine deaminases". Nucleic Acids Symposium Series 51 (1): 83–84. doi:10.1093/nass/nrm042. PMID 18029597.