2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

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2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Identifiers
EC number 2.3.1.117
CAS number 88086-34-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O \rightleftharpoons CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

The 3 substrates of this enzyme are succinyl-CoA, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and H2O, whereas its two products are CoA and N-succinyl-L-2-amino-6-oxoheptanedioate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. Other names in common use include tetrahydropicolinate succinylase, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinyltransferase, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and N-succinyltransferase. This enzyme participates in lysine biosynthesis.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1KGQ, 1KGT, 2TDT, and 3TDT.

References[edit]

  • Simms SA, Voige WH, Gilvarg C (1984). "Purification and characterization of succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase from Escherichia coli". J. Biol. Chem. 259 (5): 2734–41. PMID 6365916.