2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Identifiers
EC number	1.3.1.28
CAS number	37250-40-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (EC 1.3.1.28) is an enzyme that catalyzes the chemical reaction

2,3-dihydro-2,3-dihydroxybenzoate + NAD⁺ $\rightleftharpoons$ 2,3-dihydroxybenzoate + NADH + H⁺

Thus, the two substrates of this enzyme are 2,3-dihydro-2,3-dihydroxybenzoate and NAD⁺, whereas its 3 products are 2,3-dihydroxybenzoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase. This enzyme is also called 2,3-DHB dehydrogenase. This enzyme participates in biosynthesis of siderophore group nonribosomal and [[]].

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FWM.

References

• Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli". Biochim. Biophys. Acta. 177 (3): 401–11. PMID 4306838.