2,3-dimethylmalate lyase

2,3-dimethylmalate lyase
Identifiers
EC number	4.1.3.32
CAS number	73562-28-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a 2,3-dimethylmalate lyase (EC 4.1.3.32) is an enzyme that catalyzes the chemical reaction

(2R,3S)-2,3-dimethylmalate $\rightleftharpoons$ propanoate + pyruvate

Hence, this enzyme has one substrate, (2R,3S)-2,3-dimethylmalate, and two products, propanoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming). Other names in common use include 2,3-dimethylmalate pyruvate-lyase, and (2R,3S)-2,3-dimethylmalate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

References

• Pirzer P, Lill U, Eggerer H (1979). "Nicotinic acid metabolism. 2,3-Dimethylmalate lyase". Hoppe. Seylers. Z. Physiol. Chem. 360 (12): 1693–702. doi:10.1515/bchm2.1979.360.2.1693. PMID 527937. 
• Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U. S. A. 103 (33): 12341–6. doi:10.1073/pnas.0601635103. PMC 1562527. PMID 16894175. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1562527.