2-Oleoylglycerol

From Wikipedia, the free encyclopedia
Jump to: navigation, search
2-Oleoylglycerol
2-Oleoylglycerol.svg
Identifiers
CAS number 3443-84-3 YesY
PubChem 5319879
ChemSpider 4478086 YesY
UNII 9A2389K694 YesY
Jmol-3D images Image 1
Properties
Molecular formula C21H40O4
Molar mass 356.54 g mol−1
Density 0.958 g/cm3
Hazards
Flash point >113.0 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

2-Oleoylglycerol (2OG) is a monoacylglycerol that is found in biologic tissues. Its synthesis is derived from diacylglycerol precursors. It is metabolized to oleic acid and glycerol primarily by the enzyme monoacylglycerol lipase (MAGL).[1] In 2011, 2OG was found to be an endogenous ligand to GPR119.[2] 2OG has been shown to increase glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels following administration to the small intestine.[2]

See also[edit]

References[edit]

  1. ^ Dinh, T. P.; Carpenter, D.; Leslie, F. M.; Freund, T. F.; Katona, I.; Sensi, S. L.; Kathuria, S.; Piomelli, D. (2002). "Brain monoglyceride lipase participating in endocannabinoid inactivation". Proceedings of the National Academy of Sciences 99 (16): 10819–10824. doi:10.1073/pnas.152334899. PMC 125056. PMID 12136125.  edit
  2. ^ a b Hansen, K. B.; Rosenkilde, M. M.; Knop, F. K.; Wellner, N.; Diep, T. A.; Rehfeld, J. F.; Andersen, U. B.; Holst, J. J.; Hansen, H. S. (2011). "2-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans". Journal of Clinical Endocrinology & Metabolism 96 (9): E1409–E1417. doi:10.1210/jc.2011-0647. PMID 21778222.  edit