2-Hexanone

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2-Hexanone[1][2]
Skeletal formula of hexan-2-one
Ball-and-stick model of hexan-2-one
Names
IUPAC name
Hexan-2-one
Other names
Methyl butyl ketone; Methyl n-butyl ketone; MNBK; Butyl methyl ketone; MBK; n-Butyl methyl ketone; Propylacetone
Identifiers
591-78-6 YesY
ChEMBL ChEMBL195861 YesY
ChemSpider 11095 YesY
EC number 209-731-1
Jmol-3D images Image
PubChem 154889
RTECS number MP1400000
Properties
C6H12O
Molar mass 100.16 g·mol−1
Appearance Colorless to light yellow liquid
Odor sharp
Density 0.8113 g/cm³
Melting point −55.5 °C (−67.9 °F; 217.7 K)
Boiling point 127.6 °C (261.7 °F; 400.8 K)
1.4% (14 g/L)
Vapor pressure 1.3 kPa (20 °C)
1.403 (20 °C)
Viscosity 0.63 mPa·s (20 °C)
Hazards
EU classification Toxic T
R-phrases R10, R48, R23, R62, R67
NFPA 704
Flammability code 3: Liquids and solids that can be ignited under almost all ambient temperature conditions. Flash point between 23 and 38 °C (73 and 100 °F). E.g., gasoline) Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Flash point 25 °C (77 °F; 298 K)
423 °C (793 °F; 696 K)
2590 mg/kg (oral, rat), 2430 mg/kg (oral, mouse), 4860 mg/kg (dermal, rabbit)
US health exposure limits (NIOSH):
TWA 100 ppm (410 mg/m3)
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

2-Hexanone (methyl butyl ketone, MBK) is a ketone used as a general solvent and in paints. It dissolves cellulose nitrate, vinyl polymers and copolymers, and natural and synthetic resins. It has a very low MAK value and is recommended as a solvent because it is photochemically inactive.[3]

2-Hexanone is absorbed through the lungs, orally and dermally. Its metabolite 2,5-Hexanedione is neurotoxic.[4] Animal tests have shown that the neurotoxic effect of 2-hexanone may be potentiated by simultaneous administration of 2-butanone (Methyl ethyl ketone, MEK).[5]

References[edit]

  1. ^ Merck Index, 11th Edition, 5955.
  2. ^ CRC Handbook of Chemistry and Physics, 75th ed. (1995)
  3. ^ Dieter Stoye (2007), "Solvents", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, p. 56 
  4. ^ Jerrold B. Leikin; Frank P. Paloucek (2008), "2-Hexanone", Poisoning and Toxicology Handbook (4th ed.), Informa, p. 737 
  5. ^ Wilhelm Neier; Günter Strehlke (2007), "2-Butanone", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, p. 6