- December 21, 2000: Tim Raines signed as a Free Agent with the Montreal Expos.
- December 21, 2000: Curtis Pride was signed as a Free Agent with the Montreal Expos.
Regular season 
- April 6, 2001 - In an era where the only bright spot for Expos fans was Vladimir Guerrero, another bright spot emerges as hero Tim Raines returns to Montreal for one last hurrah. In Rock's first at-bat back at the Big O he drew a walk off Glendon Rusch. Throughout the whole at-bat every Expo fan at the stadium stood and clapped for Timmy...all 45,183 of them.
- In a season that ended with talks of contraction, Felipe Alou was released as the Expos manager. He was replaced by former Chicago White Sox manager Jeff Torborg. Future White Sox manager Ozzie Guillén was a coach for the Expos.
Opening Day starters 
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Season standings 
Season schedule 
- July 31, 2001: Milton Bradley was traded by the Montreal Expos to the Cleveland Indians for Zach Day.
- July 31, 2001: Ugueth Urbina was traded by the Montreal Expos to the Boston Red Sox for Tomokazu Ohka and Rich Rundles (minors).
Player stats 
Note: G = Games played; AB = At Bats; H = Hits; Avg. = Batting Average; HR = Home Runs; RBI = Runs Batted In
Other batters 
Starting pitchers 
Other pitchers 
Relief pitchers 
Award winners 
2001 Major League Baseball All-Star Game
Farm system